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Tuesday!!!High-dose painkillers increase heart attack risk
Reuters Health - headlinesAt high doses, both the older anti-inflammatory painkillers known as NSAIDs and the newer COX-2 inhibitors (dubbed coxibs) modestly increase the risk of heart attacks in patients with arthritis, investigators report.
This means, they say, that painkillers should be chosen based on their relative gastrointestinal and cardiovascular safety profiles, rather than their class. Dr. Gurkipal Singh and colleagues at the Stanford University School of Medicine, California, looked at the risk of heart attack in more than 650,000 adults diagnosed with arthritis and treated with NSAIDs or selective COX-2 inhibitors between January 1999 and June 2004. The researchers found that many, but not all, NSAIDS increased the probability of heart attacks: indomethacin by 71 percent, sulindac by 41 percent, and ibuprofen by 11 percent. Among the coxibs, rofecoxib increased the risk by 32 percent and celecoxib by 9 percent. |
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